How can you tell if you or someone you love might have transthyretin amyloid cardiomyopathy (ATTR-CM)?

UNDERSTAND THE SIGNS AND SYMPTOMS

Did you know that some seemingly unrelated signs and symptoms could be caused by ATTR-CM? Your body may be sending you a message.

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FATIGUE

(excessive tiredness)

“I’m tired all of the time.”
TENDON RUPTURE

(eg, biceps, Achilles tendon)

“There is a painful lump in my upper arm.”
GASTROINTESTINAL ISSUES

(eg, diarrhea, constipation, nausea, or feeling full quickly)

“It seems like my stomach is more sensitive lately.”
SHOULDER, HIP, AND/OR KNEE PAIN
“It’s been years since I had my hip replaced.”
SWELLING IN LOWER LEGS

(known as peripheral edema)

“My lower legs and feet look swollen and puffy all the time these days.”
Eye Disorders

(eg, glaucoma)

“I have a past medical history of glaucoma.”
SHORTNESS OF BREATH
“Sometimes I feel like I can't catch my breath.”
Irregular Heartbeat

(known as cardiac arrhythmia)

“My doctor says I have an abnormal heartbeat.”
bILATERAL CARPAL
TUNNEL SYNDROME

(numbness, tingling, or pain in your fingers)

“I’ve had carpal tunnel syndrome in both wrists for years now.”
Pain or Numbness in Lower Back/Legs Due to Narrowing of Lower Spine

(known as lumbar spinal stenosis)

“My doctor told me my back pain is caused by something called lumbar spinal stenosis.”
Decreased or Strange Tingling Sensation/Pain in Toes/Feet

(known as peripheral neuropathy)

“It feels like my feet are always falling asleep.”

These examples are for illustrative purposes only. Signs and symptoms may vary from patient to patient.

If your doctor suspects ATTR-CM, they may conduct certain diagnostic tests.

NEXT: How ATTR-CM Is Diagnosed Loading

PP-VYN-IRL-0345 |AUG2025