YOUR HEART'S MESSAGE

ABOUT

ATTR-CM

ATTR-CM is a rare, life-threatening,
underrecognised, and underdiagnosed
type of amyloidosis that affects the heart
​​​​​​​and is associated with heart failure.

MEET H.A.R.V: A Holographic Augmented Reality Videogram

Take a journey inside the heart to learn more about ATTR-CM


SEE WHAT HAPPENS INSIDE YOUR BODY WHEN YOU HAVE ATTR-CM


Watch the video or scroll down to learn more.

The liver produces transthyretin, a transport protein that carries the hormone thyroxine and vitamin A (retinol) throughout the bloodstream.

When someone has ATTR-CM, either due to ageing (wild-type) or an inherited genetic variant (hereditary), the protein becomes unstable and misfolds.

Over time, the misfolded proteins join together and build up in the body, including in the heart (causing the heart muscle to thicken and stiffen, eventually leading to heart failure).

THERE ARE 2 TYPES OF ATTR-CM

WILD-TYPE ATTR-CM (wtATTR):


  1. ​​​​​​​
    ​​​​​​​
    • Associated with ageing
    • Most often affects white men over the age of 60
    • May be the most common form of ATTR-CM

HEREDITARY ATTR-CM (hATTR): 

    • Caused by a change (or “mutation”) in one of your genes
    • Passed down from a relative
    • Affects both men and women, with symptoms beginning as early as 50 to 60 years old
    • There are more than 120 known mutations that cause hATTR-CM 
    • In the Irish population, the T60A mutation is the most common mutation that can affect both the heart and nerves leading to cardiac failure and polyneuropathy